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Irbesartan stops angiotensin II binding towards the AT1 receptor in tissues like vascular easy muscle mass along with the adrenal gland. Irbesartan and its Lively metabolite bind the AT1 receptor with 8500 instances additional affinity than they bind to your AT2 receptor.
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Irbesartan isn't going to inhibit ACE or renin or have an impact on other hormone receptors or ion channels recognised for being involved in the cardiovascular regulation of blood pressure and sodium homeostasis.
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Irbesartan is a particular competitive antagonist of AT1 receptors with a A great deal increased affinity (a lot more than 8500-fold) for that AT1 receptor than with the AT2 receptor, and no agonist action.
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